Guided MRI Reconstruction via Schrödinger Bridge

Magnetic Resonance Imaging (MRI) is an inherently multi-contrast modality, where cross-contrast priors can be exploited to improve image reconstruction from undersampled data. Recently, diffusion models have shown remarkable performance in MRI reconstruction. However, they still struggle to effectively utilize such priors, mainly because existing methods rely on feature-level fusion in image or latent spaces, which lacks explicit structural correspondence and thus leads to suboptimal performance. To address this issue, we propose I²SB-Inversion, a multi-contrast guided reconstruction framework based on the Schrödinger Bridge (SB). The proposed method performs pixel-wise translation between paired contrasts, providing explicit structural constraints between the guidance and target images. Furthermore, an inversion strategy is intro-duced to correct inter-modality misalignment, which often occurs in guided reconstruction, thereby mitigating artifacts and improving reconstruction accuracy. Experiments on paired T1- and T2-weighted datasets demonstrate that I²SB-Inversion achieves a a high acceleration factor of R=11.38 and consistently outperforms existing methods in both quantitative and qualitative evaluations.