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Distinct triglyceride-associated lipid profiles in coronary artery ectasia and ascending thoracic aortic aneurysm: A

Yuhan Qin1, Ziqi Sha1, Xudong Li1

  • 1Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

Science Progress
|August 18, 2026
PubMed

Insights

Elevated triglycerides (TG) are linked to coronary artery ectasia (CAE), but not consistently to ascending thoracic aortic aneurysm (ATAA). This suggests distinct triglyceride-related metabolic patterns in these vascular dilative disorders.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Lipid Metabolism

Background:

  • Coronary artery ectasia (CAE) and ascending thoracic aortic aneurysm (ATAA) are dilative vascular disorders with incompletely understood lipid profiles.
  • Lipid parameters, particularly triglycerides (TG), require further investigation in relation to CAE and ATAA.

Purpose of the Study:

  • To compare lipid profiles, with a focus on TG, in patients with CAE, ATAA, and controls.
  • To assess the independent association of lipid parameters with CAE and ATAA.

Main Methods:

  • Retrospective single-center case-control study involving 490 patients with CAE, 490 with ATAA, and 490 controls.
  • Lipid associations were analyzed using multivariable logistic regression, restricted cubic splines, and subgroup analyses.

Main Results:

  • CAE patients exhibited higher TG and lower HDL-C compared to controls.
  • ATAA patients showed higher lp(a), lower TC, LDL-C, and HDL-C than controls.
  • Elevated TG was independently associated with CAE (OR=1.63, 95% CI: 1.34-1.91) with a non-linear dose-response, but not consistently with ATAA.

Conclusions:

  • CAE and ATAA present distinct lipid profiles.
  • Elevated TG is an independent risk factor for CAE, indicating a specific metabolic link.
  • The findings suggest differing triglyceride-related metabolic pathways in coronary versus aortic dilative disorders.

Keywords:
ascending thoracic aortic aneurysmcoronary artery ectasialipidtriglyceride

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