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Impaired Cardiac Myosin Super-Relaxation as an Energy-Dissipating Process in Human Heart Failure with Reduced
Weikang Ma1, Chahida Chaami2, Elise Gerlach Melhedegaard2
1BioCAT, Department of Biology, Illinois Institute of Technology, Chicago, Illinois, USA; Center for Synchrotron Radiation Research and Instrumentation, Illinois Institute of Technology, Chicago, Illinois, USA; Pritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.
None:
Systolic heart failure is increasingly recognized as a disease of impaired cardiac energy metabolism. Here, the authors show that cardiac myosin super-relaxation (an energy-conserving myosin state) is destabilized in failing human myocardium. Importantly, this loss of energy conservation is associated with elevated post-translational modifications (phosphorylation and acetylation) rather than gross structural changes in thick filament organization. Hence, targeting post-translational modifications signaling pathways opens new therapeutic opportunities.
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