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Pseudofracture: An Acute Peripheral Tissue Trauma Model
Published on: April 18, 2011
Hallmarks of the multidimensional immune response to trauma in humans
Markus Huber-Lang1, Tianmeng Chen2, Rebecca Halbgebauer3
1Institute of Clinical and Experimental Trauma Immunology, Ulm University Medical Center, Ulm, Germany. markus.huber-lang@uniklinik-ulm.de.
Abstract:
Trauma disrupts the structure-function interplay of life, instantly engaging innate and adaptive immunity together with neuroendocrine, endovascular and metabolic axes. The immune response emerges from disturbances in overarching hallmarks of any living being-barrier systems, molecular communication and adaptation-further shaped by patient-specific, injury-specific and modern care-specific determinants. These factors drive adaptive or maladaptive immune trajectories, from restitution to chronic dysfunction or death. Multi-omics analyses of trauma cohorts now enable endotype discovery, providing a framework for mechanism-guided, spatiotemporal precision immunomodulation. This Review focuses exclusively on human studies to conceptualize major themes in clinical trauma immunology to guide future research.
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