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Association Between Atherogenic Index of Plasma and Risk of Cardiovascular Disease: A Dose-Response Meta-Analysis of

Taifeng Chen1, Jinliang Liang1, Yaqin Su1

  • 1Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Medical School, Shenzhen, China.

Journal of Evidence-Based Medicine
|August 19, 2026
PubMed

Insights

Elevated atherogenic index of plasma (AIP) is linked to increased cardiovascular disease (CVD) morbidity and mortality. This association shows a dose-response relationship, indicating AIP

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Epidemiology

Background:

  • The atherogenic index of plasma (AIP) is a lipid parameter.
  • Cardiovascular disease (CVD) remains a leading cause of mortality worldwide.
  • Understanding predictive markers for CVD is crucial for public health.

Purpose of the Study:

  • To systematically evaluate the correlation between AIP and CVD morbidity and mortality.
  • To investigate the potential dose-response relationship between AIP levels and CVD outcomes.

Main Methods:

  • A comprehensive literature search was conducted across major databases (PubMed, Embase, Web of Science, CNKI, WanFang, VIP) until January 2026.
  • Included studies were cohort studies analyzing AIP and CVD incidence or death.
  • Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated, with restricted cubic splines used to assess dose-response relationships.

Main Results:

  • Analysis of 24 studies revealed significantly higher CVD morbidity (RR=1.35) and mortality (RR=1.49) in the highest AIP groups.
  • A per-unit increase in AIP was associated with a 47% increase in CVD morbidity (RR=1.47) and a 42% increase in CVD mortality (RR=1.42).
  • Linear dose-response relationships were observed between AIP and both CVD morbidity (p=0.659) and mortality (p=0.619).

Conclusions:

  • Elevated AIP is correlated with increased CVD morbidity and mortality.
  • A significant dose-response relationship exists, suggesting AIP as a potential predictor for CVD.
  • These findings support AIP's role in early clinical identification and intervention for high-risk populations.
Abstract

Keywords:
atherogenic index of plasmacardiovascular diseasecohort studydose–response relationshipmeta‐analysis

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