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Financial toxicity in reproductive system cancers: A systematic review and meta-analysis

Duygu Ürek1, Birol Yetim2, Özgür Uğurluoğlu3

  • 1Faculty of Health Sciences, Department of Health Management, Karadeniz Technical University, Trabzon, Türkiye.

Journal of Psychosocial Oncology
|August 19, 2026
PubMed
Abstract

Insights

Financial toxicity in reproductive cancers is generally mild, though males and US patients report higher levels. Awareness and interventions are key to improving patient outcomes and care access.

Area of Science:

  • Oncology
  • Health Economics
  • Cancer Survivorship

Background:

  • Financial toxicity poses a significant challenge for individuals diagnosed with reproductive system cancers.
  • Understanding the economic burden is crucial for comprehensive patient care and support.

Purpose of the Study:

  • To systematically evaluate the prevalence and severity of financial toxicity among patients and survivors of reproductive system cancers.
  • To identify factors influencing financial toxicity in this population.

Main Methods:

  • A systematic review and meta-analysis were conducted adhering to PRISMA guidelines.
  • A comprehensive literature search was performed across four major electronic databases.
  • Data from 67 reviewed studies, including 9 meta-analyzed studies, were synthesized.

Main Results:

  • The overall level of financial toxicity associated with reproductive system cancers was found to be mild.
  • Subgroup analyses indicated that male patients and those in the USA experienced higher levels of financial toxicity.
  • The meta-analysis synthesized data from 9 relevant studies.

Conclusions:

  • Raising awareness of financial toxicity is essential for supporting cancer patients and survivors.
  • Implementing targeted policies and interventions can mitigate financial toxicity, improve healthcare access, and enhance health outcomes.
Keywords:
Cancerfinancial toxicitymeta-analysisreproductive systemsystematic review

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