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Updated: Aug 21, 2026
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Sulfonyl-substituted zinc phthalocyanine micelles with long-lived triplet states enable durable photodynamic
Paweł Repetowski1,2, Marta Warszyńska1,2, Fabienne Dumoulin3
1Faculty of Chemistry, Jagiellonian University Kraków 30-387 Poland jdabrows@chemia.uj.edu.pl.
Abstract:
Pluronic® P123 micelles stabilized a sulfonyl-substituted zinc(ii) phthalocyanine, prolonged its triplet-state lifetime, and preserved ROS photochemistry under biologically relevant conditions. Pharmacokinetic-guided C-PDT at a 24 h DLI remained insufficient as monotherapy, whereas combination with PD-L1 blockade produced durable tumor control. Rechallenge experiments after PDT additionally revealed complete long-term antitumor immune memory.
