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Updated: Aug 21, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

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Conformationally Constrained Phosphonate Backbone Linkages Enhance CpG Oligonucleotide Activation of Toll-Like

Ivana Kóšiová1, Ivan Štěpánek1, Ondřej Šimák1

  • 1Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, Prague 6 166 10, Czech Republic.

ACS Pharmacology & Translational Science
|August 19, 2026
PubMed

Keywords:
CpG oligonucleotidesTLR9TLR9 agonistsbackbone conformationphosphonate internucleotide linkagessolid-phase oligonucleotide synthesis

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