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Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Integrating atmospheric stability and radioepidemiological models to assess leukemia risk after a hypothetical
Renildes Freita1, Antônio César Leite1, Wagner Vasconcelos1
1Nuclear Engineering Graduate Program, Military Institute of Engineering (IME), Praça General Tibúrcio 80, Urca, 22290-270, Rio de Janeiro, Brazil.
Abstract:
This study examines how atmospheric stability influences radionuclide distribution and leukemia risk among younger populations. By integrating computational simulations with radioepidemiological frameworks and quantum geographic information system-based demographic analysis, this research introduces radiological risk density, which quantifies the intersection of biological vulnerability and population concentration. The study identifies 2-y-old females as the most vulnerable demographic, connecting to the excess relative risk. Additionally, the results reveal that the radiological impact is primarily driven by the critical overlap between high-stability local climates and sensitive demographic zones, rather than by distance from the source term alone. This shift from physical modeling to socio-epidemiological realities underscores the need for adaptive radiological protection strategies that incorporate local climate dynamics and demographics, ultimately enhancing urban resilience and prioritizing public health interventions in high-risk areas.
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