Tool for Implementing TArget Trial emulatioNs (TITAN): first version of an open-access design assistant

Target trial emulation offers a structured framework to reduce bias in observational studies by emulating the design of a hypothetical target randomized controlled trial. Despite a growing interest for this framework, the implementation of target trial emulation is often inconsistent, with design flaws frequently introducing avoidable biases. Our objective was to develop a design assistant tool to provide structured guidance to researchers for planning and conducting target trial emulations.

A multidisciplinary steering committee defined the scope, content, and structure of Tool for Implementing TArget Trial emulatioNs (TITAN). First, we reviewed the literature to identify concepts according to the steps of planning and designing a target trial emulation. Then, we developed the tool through an iterative process with two rounds of pilot testing and subsequent refinement by the steering committee.

TITAN provides guidance to emulate a pragmatic two-arm trial assessing a pharmacological intervention. The tool is organized in two main sections. First, the users define the research question and the target trial. Then, they emulate the target trial using the available observational data. The tool provides warnings, in addition to suggestions, to potentially minimize avoidable biases and major methodological errors, particularly focusing on the alignment of study time points (eligibility, treatment assignment, and start of follow up) and related biases. The tool's output is a synthesis that includes a summary of the target trial, design of its emulation, and possible biases and solutions.

TITAN could help researchers ensure that observational studies follow the key principles of target trial emulation.