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Updated: Aug 21, 2026
Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
Autoimmune cytopenia after allogeneic haematopoietic stem cell transplantation - A single-center case series
Yingqi Wang1, Yeow-Tee Goh1, Aloysius Ho1
1Department of Haematology, Singapore General Hospital, 20 College Rd, 169856, Singapore.
Introduction:
We analysed in detail the clinical course of 16 patients with autoimmune cytopenia (AIC) after allogeneic haematopoietic stem cell transplant (allo-HSCT).
Methods:
Patients with AIC reported retrospectively by physicians were studied for their clinical characteristics, treatment, response and long-term outcome.
Results:
Sixteen patients including 10 with immune thrombocytopenic purpura (ITP), 3 with autoimmune hemolytic anemia (AIHA) and 3 with Evans syndrome (ES) were analysed. Recipients of unrelated (n = 6) and haploidentical (n = 8) donors, especially of partial T cell depleted grafts (n = 7) predominated. Onset occurred from months to years after transplant and cytopenia was severe. First-line treatment including glucocorticoids, intravenous immunoglobulin (IVIg), as monotherapy or in combination, for all patients, as well as Eltrombopag for ITP. Eight of the 10 ITP patients, 2 of 3 AIHA and 1 of 3 ES patients responded to first-line therapy, while others required further lines of treatment. Recurrence of the AIC occurred in 5 patients, where response was achieved readily or could be challenging. Overall, all 16 patients responded with no mortality due to AIC.
Conclusion:
Response of AIC after allo-HSCT to first-line treatment is heterogeneous and long-term course is variable, but even the most refractory cases can respond to a combination of treatments.
