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CARM1: an epigenetic brake on cDC1-mediated antitumor immunity

Congliang Chen1, Xuetao Cao1

  • 1Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.

Trends in Immunology
|August 19, 2026
PubMed

Insights

Tumor microenvironments impair dendritic cells (cDC1) via CARM1. Inhibiting CARM1, an epigenetic regulator, may enhance anti-tumor immunity and immunotherapy strategies.

Area of Science:

  • Immunology
  • Epigenetics
  • Cancer Biology

Background:

  • The tumor microenvironment (TME) can suppress anti-tumor immune responses.
  • Conventional type 1 dendritic cells (cDC1) are crucial for initiating adaptive immunity against tumors.
  • The mechanisms by which the TME causes cDC1 dysfunction are not fully understood.
Keywords:
CARM1TGFβcDC1epigenetic mechanismstumor immunotherapy

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