Related Experiment Video

Updated: Aug 21, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Real-world clinical outcomes after cardiac resynchronization therapy in cardiac sarcoidosis

Yoshiyasu Aizawa1, Kenji Yodogawa2, Shuhei Okajima1

  • 1Department of Cardiovascular Medicine, Nippon Medical School Hospital, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.

Heart and Vessels
|August 20, 2026
PubMed

Insights

Cardiac resynchronization therapy (CRT) improved QRS duration and NYHA class in cardiac sarcoidosis (CS) patients. However, limited reverse remodeling and poor clinical outcomes were observed, highlighting the disease

Area of Science:

  • Cardiology
  • Electrophysiology
  • Immunology

Background:

  • Cardiac sarcoidosis (CS) is a severe inflammatory heart condition leading to arrhythmias and heart failure.
  • The effectiveness of cardiac resynchronization therapy (CRT) in CS patients is not well-established.
  • Understanding CRT outcomes in CS is crucial for managing this complex disease.

Purpose of the Study:

  • To evaluate the efficacy and clinical outcomes of CRT in patients with cardiac sarcoidosis.
  • To assess changes in cardiac function and patient status following CRT implantation in CS.
  • To identify factors influencing CRT response in this specific patient population.

Main Methods:

  • Retrospective analysis of 19 CS patients who underwent CRT implantation (CRT-P or CRT-D) between 2007 and 2024.
  • Data collected included baseline characteristics, device information, QRS duration, NYHA functional class, LVESV, and LVEF.
  • Follow-up assessments evaluated clinical events, including hospitalizations, appropriate ICD shocks, and mortality.

Main Results:

  • CRT implantation led to significant QRS duration shortening (172±34 to 128±27ms) and NYHA class improvement (2.6±0.8 to 2.1±1.0).
  • Left ventricular volumes (LVESV) and ejection fraction (LVEF) showed no significant improvement post-CRT.
  • The cohort experienced significant morbidity and mortality, including heart failure hospitalizations, ICD shocks, and deaths from progressive heart failure.

Conclusions:

  • While CRT improves electrical conduction and functional class in CS patients, it demonstrates limited echocardiographic reverse remodeling.
  • Clinical outcomes remain poor, suggesting the advanced and heterogeneous nature of cardiac sarcoidosis impacts CRT effectiveness.
  • Further comparative studies are needed to optimize CRT strategies for patients with cardiac sarcoidosis.

Keywords:
Cardiac resynchronization therapyECGHeart failurePrognosisSarcoidosis

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