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Characterisation of the Novel HLA-C*06:390 Allele by Next-Generation Sequencing

Qi Li1, Nanying Chen1, Fang Wang1

  • 1HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.

HLA
|August 20, 2026
PubMed

Abstract:

HLA-C*06:390 differs from HLA-C*06:02:01:01 by one single nucleotide substitution in exon 2.

Keywords:
HLA‐C*06:390next‐generation sequencingnovel allele

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...

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