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Updated: Aug 21, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
Group-level versus individualized approaches for capturing tau PET changes and clinical progression in Alzheimer's
Hannah de Bruin1,2,3, Colin Groot1,2, Zeyu Zhu3
1Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.
Introduction:
Quantification approaches based on group-level regions of interest (ROIs) are widely used for evaluating tau positron emission tomography (PET) and clinical progression in Alzheimer's disease (AD), but we hypothesize that personalized approaches better capture inter-individual heterogeneity.
Methods:
We included 556 amyloid beta-positive individuals from seven cohorts (335 cognitively unimpaired [CU]; 221 cognitively impaired [CI]) with ≥ 2 [18F]flortaucipir (tau) PET scans. We compared three group-level and seven individualized tau PET quantification approaches (and a voxel-wise spatial extent metric) by (1) percentage change, (2) sensitivity to change, and (3) clinical associations.
Results:
Percentage change was highest in a composite temporal ROI (temporal-meta) in CU and CI. Individualized Braak stage-based (CU) and connectivity-informed (CU/CI) approaches, and tau spatial extent (CI), performed well for sensitivity to change and clinical associations, but temporal-meta was consistently a top performer.
Discussion:
Contrary to our hypothesis, temporal-meta quantification was most robustly associated with biological and clinical progression across disease stages, making it well suited for monitoring AD progression with tau PET.
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