Serum von Willebrand Factor and Thymic Stromal Lymphopoietin Levels Are Associated With Asthma Predictive Index in

Related Experiment Video

Updated: Aug 21, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

E Mancino1, R Nenna1, L Petrarca1

  • 1Department of Maternal Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.

Acta Paediatrica (Oslo, Norway : 1992)
|August 20, 2026
PubMed

Insights

Biomarkers thymic stromal lymphopoietin (TSLP) and von Willebrand factor (vWF) may improve asthma prediction in children with recurrent wheezing. Elevated levels of TSLP and vWF were associated with a positive Asthma Predictive Index (API) score.

Area of Science:

  • Pediatric Pulmonology
  • Biomarker Discovery
  • Asthma Research

Background:

  • Recurrent wheezing affects many preschoolers, with a third developing asthma.
  • Early risk stratification for asthma is crucial for timely intervention.
  • The Asthma Predictive Index (API) aids in risk assessment, but its accuracy can be enhanced.

Purpose of the Study:

  • To investigate the potential of biological markers, specifically thymic stromal lymphopoietin (TSLP) and von Willebrand factor (vWF), in improving asthma risk prediction.
  • To assess the association between TSLP and vWF levels and the Asthma Predictive Index (API) in children with recurrent wheezing.

Main Methods:

  • A prospective cohort study enrolled 92 children aged 1-5 years with recurrent wheezing.
  • The Asthma Predictive Index (API) was used to classify children into API-positive and API-negative groups.
  • Blood samples were analyzed for complete blood count, total Immunoglobulin E, TSLP, and vWF levels.

Main Results:

  • TSLP and vWF levels were significantly higher in API-positive children compared to API-negative children (p=0.045 for TSLP, p=0.012 for vWF).
  • Multivariable analysis confirmed that elevated TSLP and vWF were independently associated with API positivity.
  • Median TSLP was 0.473 fg/mL and median vWF was 107.4% in the study cohort.

Conclusions:

  • Findings suggest a potential association between vWF, TSLP, and API status in predicting asthma risk.
  • Further longitudinal studies are necessary to validate the predictive value of these biomarkers for future asthma development.
  • TSLP and vWF may serve as valuable adjuncts to the API for early asthma risk stratification.
Abstract

Keywords:
asthma predictionbiomarkerspreschool wheezingthymic stromal lymphopoietinvon Willebrand factor

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