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Related Experiment Videos

Huntington's chorea and tryptophan.

W R McLeod, D J Horne

    Journal of Neurology, Neurosurgery, and Psychiatry
    |August 1, 1972
    PubMed
    Summary
    This summary is machine-generated.

    Daily supplementation with l-tryptophan and pyridoxine did not worsen motor skills in Huntington's chorea patients. This study assessed the safety of these nutrients for individuals with this neurodegenerative disorder.

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    Area of Science:

    • Neuroscience
    • Nutritional Science

    Background:

    • Huntington's chorea is a progressive neurodegenerative disorder.
    • Motor skill deterioration is a key symptom of Huntington's chorea.

    Purpose of the Study:

    • To evaluate the effect of l-tryptophan and pyridoxine supplementation on manual motor skills in Huntington's chorea patients.
    • To assess the safety of daily l-tryptophan and pyridoxine intake in this patient group.

    Main Methods:

    • A small group of Huntington's chorea patients received daily doses of 7 g l-tryptophan and 70 mg pyridoxine.
    • Supplementation was administered for a duration of 14 days.
    • Objectively measured manual motor skills were assessed.

    Main Results:

    • No deterioration in objectively measured manual motor skills was observed.

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  • The supplementation regimen was tolerated without apparent negative effects on motor function.

    • Conclusions:

    • Short-term daily supplementation with l-tryptophan and pyridoxine appears safe regarding manual motor skills in Huntington's chorea.
    • Further research is warranted to explore potential therapeutic benefits or long-term effects.