Related Experiment Videos
Divergent trends in Alzheimer's disease burden: a comparative analysis of the US and G20 nations
Yuexiao Zou1, Qingxian Wang1, Qingxiang Zhang1
1Shandong University of Traditional Chinese Medicine, Jinan, China.
Objective:
Alzheimer's disease and other dementias (ADOD) impose growing systemic stress. This study compared epidemiological trends and risk factors between the US and G20 to guide resource allocation.
Methods:
Using GBD 2023 data, we analyzed incidence, mortality, and DALY rates with Joinpoint regression (1990-2023) and ARIMA forecasting (to 2040).
Results:
In 2023, US age-standardized incidence rate was 130 (95% CI: 110.5-147.3), mortality rate 30 (7.4-73.2), and DALY rate 510 (224.8-1059.6), all declining from 1990. G20 rates remained lower but showed an upward inflection after 2020. Joinpoint analysis revealed overall downward trends, with a transient US resurgence (1998-2004); projections suggest continued deceleration. Smoking and high fasting plasma glucose burdens in the US were disproportionately elevated compared to G20.
Conclusion:
The US achieved morbidity compression yet faced rising absolute caseloads due to demographic momentum. G20's post-2020 upturn signals an emerging burden. A shift from smoking to metabolic drivers necessitates primary prevention for G20 and targeted metabolic management for the US.
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction
Dementia l: Introduction
Dementia
The progression of dementia is generally gradual.
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Alzheimer's Disease: Treatment