A novel cucurbit[6]uril derivative-based integrated SPME-GC analysis system for efficiently determining the migration...

The migration of harmful plastic additives with diverse polarities and boiling points from plastic food contact materials (FCMs) poses a risk to human health, necessitating simple and effective analytical methods. Herein, a π-conjugated truxene (Tr) was covalently bonded with cucurbit[6]uril (Q[6]) to afford a novel Q[6]-Tr compound, which was fabricated as both a solid-phase microextraction (SPME) fiber coating and a gas chromatography (GC) stationary phase to establish an integrated SPME-GC system. The proposed method determined 9 plastic additives from 4 categories, showing good linearity (R² ≥ 0.9863) over 5-1000 μg/L, low detection limits (0.21-0.45 μg/L), enrichment factors of 13-42, and satisfactory recoveries (70.8-97.5%), with performance superior to commercial counterparts. Practical application quantified BHT migration from takeout containers (2.341 μg/L) and DIBP from containers and plastic bags (2.504 and 4.954 μg/L). This dual-functional Q[6]-Tr system offers an organic solvent-free, universally applicable approach for multiclass additive analysis in FCMs.