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Updated: Aug 21, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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Published on: August 5, 2022

Nicotinamide-Based Covalent Inhibitors of tRNA (m1G37) Methyltransferase (TrmD) to Increase Antibacterial Activity

Isao Masuda1, Simon D P Baugh2, Kevin McClay2

  • 1Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.

ACS Medicinal Chemistry Letters
|August 20, 2026
PubMed

Keywords:
AdoMet (S-adenosyl methionine)Antibacterial drug discoveryGram-negative bacteriaTrmD (tRNA (m1G37) methyltransferase)covalent inhibitionstructure-based drug design

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