Related Experiment Video
Updated: Aug 21, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
Published on: January 17, 2020
Supramolecular Chiral Halogen-Bonded Organic Frameworks Enhance Efficient Chirality-Induced Spin Selectivity
Congcong Zhang1, Zhongchen Xu2, Siyi Lin1
1The Institute for Advanced Studies, Hubei Key Lab On Organic and Polymeric Opto-Electronic Materials, Wuhan University, Wuhan, Hubei, China.
None:
Chirality-induced spin selectivity (CISS) has attracted extensive interest for its various potential applications. However, the development of high-spin-polarization CISS materials still represents a significant challenge. We report the design and preparation of two novel 2D chiral halogen-bonded organic frameworks (XOFs), XOF-TPH and XOF-TPO, constructed from chiral binaphthyl crown ether-based ligands. By modulating the crown ether size, we controlled the molecular flexibility and consequently the crystallinity of the XOFs. The formation of XOF-TPH/TPO was characterized by 1H NMR, XPS, IR, XAFS, PXRD, SAXS, HR-TEM, and SEAD. The frameworks exhibited pronounced Cotton effects and magnetic circular dichroism (CD), confirming their chiral nature. XOF-TPH/TPO exhibited superior charge-transport capability over the ligands. More importantly, both XOFs demonstrated significantly enhanced CISS effects compared to the monomeric ligands. This enhancement was attributed to the well-ordered framework structures and the heavy-atom effect of iodine, which amplifies spin-orbit coupling. Notably, XOF-TPH, with higher crystallinity, exhibited remarkable CISS performance with a spin polarization up to 94%, implying the crucial role of structural order. This work showed the tremendous potential of chiral XOFs for high spin selectivity and offered valuable insights into the structure-property relationship within CISS, which is crucial for the development of high-performance CISS materials.
More Related Videos
10:17Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
06:35Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
Published on: February 15, 2016
Related Concept Videos
Prochirality
Chirality at Nitrogen, Phosphorus, and Sulfur
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Molecules with Multiple Chiral Centers
Radical Halogenation: Stereochemistry
Halogenation to form a new chiral center:
Regioselectivity of Electrophilic Additions to Alkenes: Markovnikov's Rule
The hydrohalogenation of an unsymmetrical alkene can yield two haloalkane products, depending on which vinylic carbon takes up the halogen. However, one product usually predominates, where hydrogen adds to the vinylic carbon bearing the...
Chirality in Nature