Related Experiment Video
Updated: Aug 22, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
Published on: February 23, 2024
Topical MSC-Derived Extracellular Vesicles Accelerate Healing of Second-Degree Burns: A Case Report
Carl I Schulman1, Nicholas Namias1, Louis Pizano1
1Department of Surgery, Ryder Trauma Center, University of Miami School of Medicine, Miami, Florida, 1800 NW 10th Ave, Miami, FL 33136, USA.
None:
Burn injuries are challenging to treat due to wound progression and long-term scarring. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have regenerative and immunomodulatory properties that may mitigate these complications. In this Phase 1/2a, first-in-human, open-label study, a 47-year-old man with deep second-degree burns received a single topical dose of allogeneic bone marrow MSC-derived EVs within 48 hours of injury. The treated wound achieved >99% closure within one week, with durable healing for over one year. Scar outcomes improved over 52 weeks, with POSAS scores indicating early resolution of pain and pruritus and minimal residual scarring. No adverse events occurred. Laser Doppler imaging showed improved perfusion within one week, suggesting prevention of burn wound conversion. These findings support the potential of MSC-derived EVs to accelerate burn healing and reduce scar-related morbidity.
Related Concept Videos
Clinical Applications of Epidermal Stem Cells
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Mesenchymal Stem Cells
Healing II: Complications
