Obesity, lipids, inflammation, and healthy aging

Area of Science:

• Cardiovascular Science
• Metabolic Health
• Inflammation Research

Background:

• Cardiovascular disease (CVD) is a leading global cause of mortality and morbidity.
• Low-density lipoprotein-cholesterol (LDL-C) is a primary target for atherosclerotic CVD (ASCVD) prevention.
• Low-grade systemic inflammation plays a key role in atherosclerosis development and progression.

Purpose of the Study:

• To review the complex interplay between obesity, dyslipidemia, and inflammation in the context of CVD.
• To highlight the importance of optimizing these interconnected risk factors for cardiovascular health.
• To emphasize the role of these factors in healthy aging and longevity.

Main Methods:

• Literature synthesis of existing research on obesity, dyslipidemia, inflammation, and CVD.
• Analysis of population trends in CVD risk factor prevalence.
• Review of mechanisms linking obesity to atherogenic lipid profiles and inflammation.

Main Results:

• Obesity prevalence has risen dramatically, contributing to increased CVD risk through multiple pathways.
• Obesity exacerbates dyslipidemia, leading to more atherogenic lipid profiles.
• Obesity amplifies systemic inflammation, further promoting atherosclerotic processes.

Conclusions:

• Combined assessment of lipid and inflammatory biomarkers can predict long-term CVD events.
• Addressing obesity, dyslipidemia, and inflammation is critical for effective CVD prevention.
• Optimizing these risk factors is essential for achieving healthy aging and extending longevity.