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Updated: Aug 22, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
Published on: April 16, 2012
Uncovering an adaptive immune hallmark of extreme longevity
1Department of Immunology, NHC Key Laboratory of Medical Immunology (Peking University), Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; Peking University Center for Human Disease Genomics, Peking University Health Science Center, Beijing, China.
Abstract:
In a recent paper, Hashimoto et al. used single-cell profiling to reveal that supercentenarians harbor expanded, nonexhausted CD4+ cytotoxic T lymphocytes. These cells retain potent cytotoxicity and functional plasticity, suggesting an adaptive immune restructuring to manage persistent MHC class II-restricted antigens, potentially contributing to their exceptional healthy aging.
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