Related Experiment Video

Updated: Aug 22, 2026

Application of Unsupervised Multi-Omic Factor Analysis to Uncover Patterns of Variation and Molecular Processes Linked to Cardiovascular Disease
08:51

Application of Unsupervised Multi-Omic Factor Analysis to Uncover Patterns of Variation and Molecular Processes Linked to Cardiovascular Disease

Published on: September 20, 2024

Positive association and shared genetic structure between cardiovascular diseases and osteoarthritis: Insights from

Yuheng Lu1, Dexin Hu1, Fei Tian1

  • 1Department of Rehabilitation Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Therapeutic Advances in Musculoskeletal Disease
|August 21, 2026
PubMed

Insights

Osteoarthritis (OA) and cardiovascular diseases (CVDs) share a genetic link, suggesting common biological pathways contribute to both conditions. This research uncovers shared genetic factors influencing OA and CVDs, highlighting abnormal lipid metabolism as a potential common cause.

Area of Science:

  • Genetics and Epidemiology
  • Comorbidity Research
  • Molecular Biology

Background:

  • Osteoarthritis (OA) and cardiovascular diseases (CVDs) are leading causes of global disability.
  • A significant association exists between OA and CVDs, but underlying biological mechanisms are unclear.

Purpose of the Study:

  • To investigate the epidemiological link between OA and common CVDs.
  • To determine if shared genetic architecture underlies the comorbidity of OA and CVDs.

Main Methods:

  • Cross-sectional study with 21,019 participants.
  • Multivariable logistic regression to assess OA and CVD associations.
  • Genome-wide pleiotropic and multi-trait colocalization analyses using GWAS data.

Main Results:

  • Positive associations found between OA and five CVDs (angina, coronary artery disease, myocardial infarction, heart failure, stroke).
  • Significant genetic correlations (rg) observed, confirming shared genetic architecture.
  • Identified 80 pleiotropic loci, 84 pleiotropic genes (e.g., APOE), and highlighted abnormal lipid metabolism as a potential shared mechanism.

Conclusions:

  • A positive association and shared genetic basis exist between OA and CVDs.
  • Abnormal lipid metabolism is implicated as a potential common underlying mechanism.
Abstract

Keywords:
cardiovascular diseasesosteoarthritispleiotropic loci and genesshared genetic structure

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