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Factors Associated With Multivessel Coronary Artery Involvement in Patients With Coronary Artery Disease: A

Naeem A Alshoaibi1, Taha K Tasji2, Sultan Gharib2

  • 1Cardiology, King Abdulaziz University Hospital, Jeddah, SAU.

Cureus
|August 21, 2026
PubMed

Insights

Advanced age and obesity are significant factors associated with multivessel coronary artery disease requiring percutaneous coronary intervention (PCI). This study highlights these risks in patients undergoing PCI for complex coronary artery disease.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Public Health

Background:

  • Coronary artery disease (CAD) can involve single, double, or triple vessels.
  • Percutaneous coronary intervention (PCI) improves outcomes but carries risks, especially with multivessel CAD.
  • Patient factors like obesity and age can influence CAD complexity and PCI outcomes.

Purpose of the Study:

  • To identify demographic and clinical factors associated with multivessel CAD (double or triple vessel involvement) in patients undergoing PCI.
  • To compare characteristics between patients undergoing PCI for double-vessel versus triple-vessel disease.

Main Methods:

  • Retrospective observational study at Doctor Soliman Fakeeh Hospital (DSFH), Jeddah, Saudi Arabia (January 2019 - December 2024).
  • Included adult patients diagnosed with CAD who underwent PCI.
  • Categorized patients into single-vessel, double-vessel, or triple-vessel PCI groups.

Main Results:

  • 1,329 patients included: 978 single-vessel, 324 double-vessel, 27 triple-vessel PCI.
  • Patients aged ≥65 years had nearly double the odds of multivessel PCI (aOR 1.90).
  • Obese patients were over 2.5 times more likely to have multivessel involvement (aOR 2.62).

Conclusions:

  • Obesity and advanced age are significant factors associated with multivessel coronary artery disease requiring PCI.
  • These findings reinforce the link between older age, obesity, and complex CAD necessitating PCI.
  • Understanding these associations can aid in risk stratification and patient management.
Abstract

Keywords:
advanced agecoronary artery diseasemultivessel coronary artery involvementobesitypci

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