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Published on: August 23, 2019

Unveiling functional heterogeneity in pasteurized Akkermansia muciniphila identifies AKK2645 as a superior postbiotic

Yaqiong Li1, Wenfang Song2, Xiaoli Liu2

  • 1Hunan Province Directly Affiliated TCM Hospital, Zhuzhou, China.

Frontiers in Nutrition
|August 21, 2026
PubMed

Insights

Akkermansia muciniphila strain AKK2645 effectively treats metabolic syndrome by improving gut health, reducing inflammation, and restoring metabolic balance. This precision postbiotic offers a promising new therapeutic avenue for this widespread condition.

Area of Science:

  • Microbiology
  • Immunology
  • Metabolic Research

Background:

  • Metabolic syndrome (MetS) is a growing global health concern requiring novel microbiome-based treatments.
  • Significant heterogeneity exists among Akkermansia muciniphila strains regarding their therapeutic potential.

Purpose of the Study:

  • To systematically evaluate 42 pasteurized Akkermansia muciniphila strains for their efficacy in alleviating MetS.
  • To identify and characterize the most effective strain for MetS intervention.

Main Methods:

  • Systematic functional screening of 42 Akkermansia muciniphila strains using cell and mouse models.
  • Evaluation of strain AKK2645's efficacy in diet-induced obesity, glucose homeostasis, and hepatic steatosis models.
  • Analysis of host immunity modulation, gut microbiota composition, and GLP-1 signaling.

Main Results:

  • Strain Akkermansia muciniphila YGMCC2645 (AKK2645) demonstrated superior efficacy in attenuating obesity, improving glucose control, and reducing fatty liver.
  • AKK2645 modulated host immunity by decreasing pro-inflammatory cytokines and increasing anti-inflammatory markers.
  • AKK2645 favorably altered gut microbiota composition and activated intestinal GLP-1 signaling.

Conclusions:

  • Strain-specific functional differences are crucial for postbiotic efficacy in treating MetS.
  • Akkermansia muciniphila strain AKK2645 is identified as a potent, precision postbiotic for metabolic syndrome intervention.
Keywords:
AKK2645Akkermansia muciniphilafunctional heterogeneitymetabolic syndromepostbiotic

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