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Updated: Aug 22, 2026
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Multifunctional Hybrid Gels Containing Silver Nanoparticles, Gold Nanorods, and Protoporphyrin IX for Synergistic
Roberta C S Neves1, Antônio L de Oliveira2, Silvany de S Araújo3
1Programa de pós-graduação em Ciências dos Materiais, Universidade Federal de Pernambuco UFPE, Recife, Pernambuco 50.740-560, Brazil.
Abstract:
Photodynamic and photothermal therapies, enhanced by nanotechnology, show great potential in skin cancer treatment. This study reports the synthesis and characterization of hybrid sodium alginate gels conjugated with protoporphyrin-IX, associated with gold and silver nanoparticles (AgNP/AuNR⊂PpIX-Alg). Silver nanoparticles improved singlet oxygen generation under a 660 nm light (quantum yield of 26.4%), while gold nanorods achieved a 54.3% photothermal conversion efficiency at 785 nm. Dual laser irradiation (660 and 785 nm) led to a strong synergistic therapeutic effect, reducing melanoma cell viability (B16-F10) to 9.83%, with no cytotoxicity to L929 fibroblast cells. These results support AgNP/AuNR⊂PpIX-Alg as a promising platform for multimodal cancer therapy.
