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Updated: Aug 23, 2026

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
Published on: March 25, 2020
Lanolin-derived bioactive fractions promote infected wound healing via synergistic anti-inflammatory and pro-survival
Xinhai Wang1, Pilin Huang1,2, Baichen Xiong2
1School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Abstract:
Three active fractions (QS1, QS2, HC1) were isolated from lanolin by activity‑guided fractionation. They promoted proliferation, migration and cell cycle progression of keratinocytes and fibroblasts. HPLC‑Q‑TOF/MS identified 34 compounds, including ceramides and fatty acids. Mechanistically, the fractions suppressed TLR9/NF‑κB/NLRP3 inflammation in LPS‑stimulated keratinocytes and activated PI3K/Akt survival signalling in 5‑FU‑treated fibroblasts. In a S. aureus‑infected full‑thickness wound model, the fraction‑loaded hydrogel accelerated wound closure. These results reveal that lanolin‑derived bioactive fractions facilitate infected wound healing through synergistic anti‑inflammatory and pro‑survival mechanisms.
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