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Published on: May 9, 2014
Construction of NO-releasing coating on PET via layer-by-layer self-assembly
Zhaoyan Ge1, Fengni Liu1, Ziwei Chen1
1Jiangsu Collaborative Innovation Center of BiomedicalFunctional Materials, Department of Materials Science and Engineering, Schoolof Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.
None:
Nitric oxide (NO) releasing coating is promising for implantable medical devices due to the role of NO in the vascular system. In the study, a multilayered NO-releasing coating was constructed via layer-by-layer (LBL) self-assembly to improve the hemocompatibility of poly(ethylene terephthalate)(PET). A keratin-based NO donor (KSNO) was synthesized and used as a negatively-charged monolayer. Polyethyleneimine (PEI) acted as a positively-charged monolayer. The LBL coating has an adjusted KSNO payload capacity, achieving a tunable NO release in the presence of ascorbic acid (Asc). The coated PET film (n = 5) selectively promoted the proliferation of endothelial cells, while suppressing the excessive proliferation of smooth muscle cells. Furthermore, the coated film demonstrated excellent biocompatibility, along with antibacterial, antioxidant, and anti-inflammatory activities. To the best of our knowledge, it is the first time that a biomacromolecular donor of NO has been used as a monolayer for LBL self-assembly.
