Related Experiment Video
Updated: Aug 23, 2026
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
Rapid whole-brain susceptibility source separation using sub-minute three-dimensional multiple overlapping-echo
Longkun Chen1, Qinqin Yang2, Shiwei Huang1
1Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiang'an Campus, Xiamen University, Xiamen, Fujian, 361102, China.
Objective:
Magnetic susceptibility source separation provides profound insights into tissue pathophysiology by disentangling the underlying paramagnetic and diamagnetic sources within the human brain. However, the highly time-consuming nature of existing acquisition techniques creates a critical need for rapid and reliable separation methodologies to facilitate routine clinical applications.
Approach:
A highly accelerated framework for whole-brain magnetic susceptibility source separation was proposed by utilizing the ultra-fast 3D-MOLED sequence. This pipeline integrates the advanced deep learning architecture to accurately map the separated susceptibility components without relying on spin echo data. To ensure quantitative stability and structural fidelity, a robust three-dimensional domain adaptation strategy was incorporated during the simulation phase. The performance of the proposed method was systematically evaluated through phantom experiments, healthy volunteer assessments, and clinical examinations of patients with multiple sclerosis.
Main Results:
The proposed framework achieved whole-brain susceptibility source separation at 1 mm isotropic resolution with only 50 s of data acquisition. In healthy volunteers, the paramagnetic and diamagnetic susceptibility maps were highly comparable to those obtained with the conventional multi-echo gradient-echo sequence, with structural similarity indices of 0.9244 ± 0.0181 and 0.9425 ± 0.0186, peak signal-to-noise ratios of 33.76 ± 2.37 and 37.29 ± 3.51 dB, regional coefficients of determination of 0.973 and 0.934, and Bland-Altman biases of -0.0013 and -0.0010 ppm, respectively. Furthermore, clinical evaluations in patients with multiple sclerosis demonstrated consistent characterization of complex lesion-related susceptibility features.
Significance:
Achieving whole-brain magnetic susceptibility source separation in less than one minute represents a meaningful technical advance. By substantially reducing the acquisition time required for susceptibility source separation, this accelerated framework may improve the feasibility of future clinical translation in neuroimaging workflows.
