Related Experiment Video
Updated: Aug 23, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
Published on: May 18, 2020
Short-term plasticity-based working memory spiking model is resilient to synaptic heterogeneity
Gianmarco Tiddia1, Luca Sergi1,2, Simone Rubiu2
1Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Cagliari, Cagliari, Italy.
None:
The presence of activity-silent working memory has been increasingly supported by experimental observation, and short-term synaptic facilitation is suggested to underlie this phenomenon. Originally proposed in the early 2000s, the synaptic theory of working memory was supported by a relatively simple, yet powerful, computational model. Recent advancements in simulation technology eased the introduction of heterogeneity in spiking models, which is a crucial factor in enhancing their dynamical richness and biological plausibility. However, introducing such heterogeneity often disrupts previously observed network dynamics. This work investigates the impact of synaptic heterogeneity in a spiking model of working memory sustained by short-term synaptic facilitation, observing that the model is resilient to additional variability.
More Related Videos
Related Concept Videos
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation
Neuroplasticity
Integration of Synaptic Events
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression

