Predictive value of triglyceride combined with age-adjusted D-dimer in patients with early-stage cervical cancer

ObjectiveThis study aimed to evaluate the prognostic performance of preoperative serum triglyceride and age-adjusted D-dimer levels in patients with early-stage cervical cancer who underwent radical hysterectomy.MethodsWe conducted a dual-center retrospective analysis enrolling a total of 381 patients, integrating preoperative biochemical biomarkers and clinicopathological variables for statistical evaluation. Receiver operating characteristic curves and the corresponding area under the curve values were generated to quantify the predictive performance of triglyceride, age-adjusted D-dimer, and their combined signature for clinical outcomes. Cox proportional hazards regression models were used to perform univariate and multivariate analyses of progression-free survival and overall survival.ResultsA novel calculation formula for age-adjusted D-dimer was established in this cohort. Kaplan-Meier survival analysis and area under the curve results demonstrated that triglyceride and age-adjusted D-dimer individually exhibited satisfactory predictive performance for both overall survival and progression-free survival. We constructed a composite risk score based on the optimal cutoff values of triglyceride (1.45 mmol/L) and age-adjusted D-dimer (0.215 mg/L). Multivariate Cox regression identified three independent adverse prognostic factors for both progression-free survival and overall survival: maximum tumor diameter, deep stromal invasion, and score 2 (defined as triglyceride ≥ 1.45 mmol/L plus age-adjusted D-dimer ≥ 0.215 mg/L). Using these independent predictors, we developed a quantitative nomogram to estimate postoperative overall survival risk in patients with early-stage cervical cancer undergoing radical hysterectomy.ConclusionsThe composite score 2 model integrating preoperative triglyceride and age-adjusted D-dimer can effectively predict the prognosis of patients with early-stage cervical cancer after radical hysterectomy.