Related Experiment Video

Updated: Aug 23, 2026

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

Caveolin-1 levels associated with coronary artery disease in Chinese participants: a retrospective cohort study

Jiazheng Chen1, Hongli Li2, Yuxin Liang2

  • 1School of the Fifth Clinical Medicine, Shanxi Medical University, Taiyuan, China.

Frontiers in Cardiovascular Medicine
|August 22, 2026
PubMed

Insights

Lower circulating Caveolin-1 (Cav-1) levels are linked to increased coronary artery disease (CAD) risk in Chinese adults. Measuring Cav-1 may help refine CAD risk stratification beyond conventional factors.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Molecular Biology

Background:

  • Coronary artery disease (CAD) is a leading global cause of mortality, with a significant portion of risk unexplained by traditional factors.
  • Caveolin-1 (Cav-1) plays a role in endothelial function and its genetic variants are associated with CAD risk.
  • The clinical utility of circulating Cav-1 as a biomarker for CAD risk stratification is currently unknown.

Purpose of the Study:

  • To investigate the association between circulating Caveolin-1 (Cav-1) levels and the risk of coronary artery disease (CAD).
  • To evaluate the potential of Cav-1 as a clinical biomarker for CAD risk stratification.

Main Methods:

  • Retrospective cohort study of 160 participants (105 CAD patients, 55 controls) undergoing coronary angiography.
  • Serum Cav-1 levels measured via ELISA; CAD defined as ≥50% stenosis in major coronary arteries.
  • Multivariable logistic regression, restricted cubic spline (RCS), and receiver operating characteristic (ROC) curve analyses were employed.

Main Results:

  • CAD patients had significantly lower serum Cav-1 levels compared to controls (7.0 ± 2.7 vs. 8.5 ± 2.7 ng/mL, P=0.001).
  • Each 1 ng/mL increase in Cav-1 was associated with an 18% reduction in CAD risk (OR 0.82, P=0.031), showing a consistent linear inverse relationship.
  • Combining Cav-1 with albumin significantly improved discriminative performance (AUC 88.4%), approaching the full multivariable model.

Conclusions:

  • Circulating Cav-1 is independently and inversely associated with CAD risk in Chinese adults.
  • Cav-1 demonstrates potential as a novel biomarker for refining CAD risk stratification.
  • The combination of Cav-1 and albumin shows robust discriminative capability for CAD.
Abstract

Keywords:
Chinese populationalbuminbiomarkercaveolin-1coronary artery disease

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...