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Spectrum of Pregnancy-Related Acute Kidney Injury in Obstetric Patients: A Retrospective Study

Shailja Bhamri1, Devyani Misra1

  • 1Department of Obstetrics and Gynecology, Dr. Ram Manohar Lohia Institute of Medical Sciences, 21, Ishwarpuri, Sector-12 Indira Nagar, Lucknow, UP 226016 India.

Journal of Obstetrics and Gynaecology of India
|August 22, 2026
PubMed

Insights

Acute kidney injury (AKI) in obstetric patients is serious, but timely renal replacement therapy (RRT) improves recovery. Early recognition and management of AKI in pregnancy are vital for reducing maternal and perinatal complications.

Area of Science:

  • Obstetrics
  • Nephrology
  • Critical Care Medicine

Background:

  • Acute kidney injury (AKI) in obstetric patients is a significant complication.
  • It can lead to severe maternal and perinatal morbidity and mortality.
  • Understanding AKI spectrum and outcomes is crucial for clinical management.

Purpose of the Study:

  • To understand the spectrum and outcomes of AKI in obstetric patients.
  • To identify leading causes and required treatments.
  • To evaluate the impact of timely renal replacement therapy (RRT) on maternal outcomes.

Main Methods:

  • Retrospective study of 50 obstetric patients meeting KDIGO criteria.
  • Data collected on demographics, clinical presentation, AKI causes, treatments, and outcomes.
  • Follow-up for three months post-acute insult.

Main Results:

  • 56% of AKI cases occurred postpartum, 36% antenatal, 8% postabortal.
  • Leading AKI causes: hypertensive disorders (44%), hemorrhage (28%), sepsis (14%).
  • 68% required RRT; 74% achieved complete renal recovery; 12% maternal mortality.

Conclusions:

  • Timely RRT initiation in obstetric AKI is linked to favorable maternal outcomes and renal function recovery.
  • Early AKI recognition and management are essential for reducing maternal and perinatal morbidity and mortality.
Abstract

Keywords:
Acute kidney injuryMaternal mortalityObstetricsPerinatal outcomesRenal replacement therapySepsis

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