Related Experiment Video

Updated: Aug 24, 2026

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
08:55

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Published on: November 2, 2014

Regulated cell death in ovarian cancer: molecular mechanisms and therapeutic targets

Yu Liu1, Zhixing Geng1, Baofu Jia2

  • 1School of Pharmacy, Baotou Medical College, Baotou, China.

Frontiers in Cell and Developmental Biology
|August 22, 2026
PubMed

Insights

Regulated cell death (RCD) pathways offer new therapeutic targets for ovarian cancer (OC). Small-molecule compounds targeting RCD present a promising strategy for improving OC treatment outcomes and precision therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Ovarian cancer (OC) has a high malignancy rate and poor prognosis, with limited success of current targeted therapies.
  • Understanding regulated cell death (RCD) mechanisms is crucial for overcoming OC pathogenesis and therapeutic resistance.

Purpose of the Study:

  • To systematically review RCD subtypes in OC and their underlying mechanisms.
  • To summarize advances in small-molecule compounds targeting RCD pathways in OC.
  • To analyze nanodelivery systems, biomarkers, clinical trials, and clinical translation challenges for RCD-targeted OC therapies.

Main Methods:

  • Literature review of RCD mechanisms in ovarian cancer.
  • Summary of small-molecule compounds targeting RCD pathways.
  • Analysis of nanodelivery platforms, biomarkers, and clinical trials.

Main Results:

  • Elucidation of major RCD subtypes and their roles in OC.
  • Identification of innovative small-molecule compounds for RCD modulation.
  • Overview of nanodelivery strategies, predictive biomarkers, and ongoing clinical trials.

Conclusions:

  • Targeting RCD pathways with small-molecule compounds is a promising strategy for ovarian cancer precision therapy.
  • Nanodelivery platforms and predictive biomarkers are key for effective RCD modulation and patient stratification.
  • Addressing clinical translation challenges is essential for advancing RCD-targeted therapies in ovarian cancer.
Keywords:
cancer therapymechanismsovarian cancerregulated cell deathsmall-molecule compounds

More Related Videos

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-107:59

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Published on: December 5, 2020

Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.