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Genetic Engineering of an Unconventional Yeast for Renewable Biofuel and Biochemical Production
Published on: September 20, 2016
Harnessing Yeast Biodiversity for Advanced Industrial Applications
Cheng Cheng1, Yu-Zhen Li2, Zhenzhi Wang2
1School of Biotechnology and Food Engineering, Hefei Normal University, Hefei 230601, China.
None:
Budding yeast Saccharomyces cerevisiae and various non-conventional species are widely applied in the production of diverse industrial products, including pharmaceuticals, biofuels, biochemicals, and biomaterials, due to their rich natural and engineered biodiversity. This review summarizes recent advances in harnessing yeast biodiversity for industrial applications, including natural yeast diversity derived from ecological adaptation and genetic variation across diverse environments, and artificial diversity generated through adaptive laboratory evolution, metabolic or epigenetic engineering, and synthetic biology. We highlight the establishment of strain-level culture libraries and extremophilic yeasts as models for stress adaptation. In addition, we emphasize that the integration of multi-omics analysis, AI-assisted enzyme and strain engineering, and process optimization strategies are critical for the fully exploration and utilization of yeast biodiversity for efficient bioproduction.
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