Related Experiment Video
Updated: Aug 24, 2026

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
Published on: February 5, 2018
Total Synthesis of D-Fucp3NAc Containing Conjugation-Ready Pentasaccharide Repeating Unit Related to Acinetobacter
Mrinmoy Manash Bharali1,2, Abhishek Santra1,2
1Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad500007, India.
None:
Herein, we report a concise synthetic strategy for the first total synthesis of the pentasaccharide repeating unit of the capsular polysaccharide of Acinetobacter baumannii RCH51. The structurally unique pentasaccharide possesses three successive1,2-cis-glycosidic linkages and ddD-Fucp3NAc as a rare-sugar. The protected pentasaccharide was synthesized using a highly stereoselective (4 + 1) block glycosylation strategy. The ddD-Fucp3N3 monosaccharide donor was synthesized efficiently on a gram scale from easily available d-glucose. The linker-appended pentasaccharide repeating unit offers a compelling opportunity for further preparation of glycoconjugates and for immunological investigations.
Related Concept Videos
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Peptidoglycan Synthesis
Biosynthesis of Polysaccharides

