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Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Electrochemical Formal Amidation of Benzyl Halides via Radical-Polar Crossover
Boao Li1, Yuhan Zhao1, Kang Zheng1
1State Key Laboratory of Luminescent Materials and Devices, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou510640, China.
Abstract:
A straightforward strategy for the electrochemical amidation of benzyl halides via radical-polar crossover has been developed. The reaction was carried out with acetonitrile as both the solvent and the amidation reagent and (PhS)2 as a "radical shuttle". Various N-substituted acetamide products can be afforded from benzyl halides under metal- and oxidant-free electrochemical conditions. This method involved a reduction pathway and employed paired electrolysis, featuring high electron economy. Meanwhile, it also has the features of simple operation and mild reaction conditions.
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