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Does Tranexamic acid fix all bleeding in surgery?

Taylor Lonjin1, Dean Zhang2, Praveen Prasanna1

  • 1Department of Anesthesiology, Virginia Commonwealth University, Richmond, VA, United States.

Journal of the National Medical Association
|August 22, 2026
PubMed

Excessive hemorrhage is a major contributor to morbidity and mortality in perioperative settings. Tranexamic acid (TXA), a synthetic antifibrinolytic agent, effectively reduces blood loss by preventing fibrin degradation. This review summarizes the clinical applications, efficacy, and safety considerations of TXA across various surgical specialties. A comprehensive review of studies across various surgical specialties confirms TXA's efficacy in minimizing the risk of hemorrhage and transfusion needs. While TXA is a valuable tool in hemostasis, proper patient selection and dosing are crucial to avoid risks, especially in those with thromboembolic conditions or renal impairment. Further research is needed to refine dosing protocols and expand its safe use across patient populations.

Keywords:
Cardiac surgeryContraindicationsNeurosurgeryOrthopedic surgeryPediatric surgeryTranexamic acidTrauma surgery

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