Related Experiment Video

Updated: Aug 24, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
07:32

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

Miaoyu Song1, Xi Liu1, Yang Xiao1

  • 1School of Medicine Chongqing University Cancer Hospital Chongqing University Chongqing China.

Medcomm
|August 23, 2026
PubMed

Insights

Fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling impacts development and health. Understanding its dysregulation offers new therapeutic strategies for diseases like cancer and metabolic disorders.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Physiology

Background:

  • Fibroblast Growth Factor (FGF)/FGF Receptor (FGFR) signaling is crucial for embryogenesis, tissue homeostasis, metabolism, and neurodevelopment.
  • Dysregulation of FGF/FGFR signaling is linked to various diseases, including skeletal dysplasia, metabolic disorders, cancers, and neurological disorders.
  • Targeting FGF/FGFR signaling is a promising clinical strategy, but faces challenges like side effects and resistance.

Purpose of the Study:

  • To provide an overview of FGF/FGFR signaling pathways.
  • To summarize cellular and physiological functions regulated by FGF/FGFR.
  • To discuss the link between aberrant FGF/FGFR signaling and diseases.

Main Methods:

  • Literature review of FGF/FGFR signaling.
  • Analysis of cellular and physiological functions.
  • Exploration of disease associations and therapeutic strategies.

Main Results:

  • FGF/FGFR signaling plays a vital role in normal physiological processes.
  • Aberrant FGF/FGFR signaling contributes to the pathogenesis of numerous diseases.
  • Current therapeutic strategies targeting FGF/FGFR signaling have limitations.

Conclusions:

  • Targeting FGF/FGFR signaling holds therapeutic potential for various diseases.
  • Further research is needed to overcome challenges in clinical translation.
  • Optimizing targeted therapies for dysregulated FGF/FGFR signaling is essential for future clinical success.
Keywords:
FGF/FGFR signalingdiseasesdownstream signaling cascadesphysiological functionstargeted intervention

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