Synergistic Topical Therapy Using Quercetin-silver Nanoparticles and Kaempferol Gel for Psoriasis Care

The current era of nano drug delivery leverages nanoparticles to enhance the efficacy of plant-derived therapeutic agents. Recent studies indicate that silver nanoparticles (SNPs) serve as ideal carriers for drug delivery due to their versatile physicochemical properties. Quercetin is a major plant flavonoid used to treat psoriasis, wound healing, and inflammatory diseases, and has an inherent antimicrobial property.

SNPs were prepared by a rapid one-pot synthesis method and characterized using FTIR, UV-Vis spectroscopy, and XRD analysis. Investigated the effectiveness of Quercetin silver nanoparticles (QSNPs) loaded Kaempferol (Kaempferol) gel against imiquimod (IMQ) induced psoriasis and inflammation.

The Entrapment efficiency of the optimized formulation was found to be 86.78±0.08%. QSNP-loaded Kaempferol gel showed 82.28% cumulative drug release over the period of 24 hrs. The anti-inflammatory effect of the prepared gel formulation was evaluated using the in vitro HRBC membrane stabilization method and protein denaturation inhibition method.

The bio-reduction of silver in SNPs due to Quercetin conjugation reduces toxicity, verified through skin irritancy assessments. QSNPs-loaded Kaempferol gel offered a noteworthy reduction in psoriasis area-severity index (PASI) scores in the IMQ-induced psoriasis model, which is ensured by a histopathology study.

Prepared QSNPs loaded Kaempferol gel shows promising effects against IMQinduced psoriasis and inflammation. Several patents and patent applications focus on the synthesis and application of quercetin silver nanoparticles.