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What Proportion of Antibody-Negative Type 1 Diabetes Cases Have a Nonautoimmune Etiology? A Genetics-Based Estimate
Jacob L Nicodemo1, Angeliki Makri2, Constantin Polychronakos1,2
1The Endocrine Genetics Laboratory, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Article Highlights:
Accurate diagnosis of diabetes has important therapeutic consequences, yet 10-15% of individuals with type 1 diabetes are autoantibody negative, leaving the etiology of diabetes unconfirmed. We estimated what proportion of autoantibody negative, clinically diagnosed type 1 diabetes is misdiagnosed nonautoimmune diabetes. Upwards of 7.6% of autoantibody negative individuals are nonautoimmune. Our findings support the use of autoantibody screening and genetic testing of autoantibody negative patients as standard of care for type 1 diabetes.
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