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Systemic Hypertension as an Independent Risk Factor for Polypoidal Choroidal Vasculopathy: Evidence from Indian

Rupak Kanti Biswas1, Jay U Sheth2, Krishnendu Nandi1

  • 1Senior Vitreo Retina Surgeon, Netralayam - The Superspeciality Eye Care Centre, Kolkata, West Bengal, India.

Retina (Philadelphia, Pa.)
|August 24, 2026
PubMed

Insights

Hypertension is a significant risk factor for polypoidal choroidal vasculopathy (PCV). The risk is higher in elderly men, suggesting a link between high blood pressure and this eye condition.

Area of Science:

  • Ophthalmology
  • Cardiovascular Medicine
  • Medical Research

Background:

  • Polypoidal choroidal vasculopathy (PCV) is a subtype of age-related macular degeneration.
  • Understanding risk factors for PCV is crucial for early detection and management.

Purpose of the Study:

  • To investigate the association between hypertension and PCV.
  • To identify demographic groups with increased susceptibility to PCV.

Main Methods:

  • A retrospective case-control study involving 101 PCV patients and 101 controls.
  • Odds ratios (OR) were calculated to compare PCV prevalence.
  • Logistic regression adjusted for age and gender was employed.

Main Results:

  • Hypertension was more prevalent in PCV cases (84.2%) than controls (60.4%).
  • Hypertension was an independent risk factor for PCV (adjusted OR=3.43).
  • The association was stronger in males and individuals over 70 years old.

Conclusions:

  • Hypertension is a significant independent risk factor for PCV.
  • Elderly males with hypertension face an elevated risk of PCV.
  • Findings suggest a link between hypertensive vascular disease and PCV development.
Abstract

Keywords:
HypertensionIndocyanine green angiographyPachychoroidPolypoidal choroidal vasculopathy

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