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Updated: Aug 26, 2026

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice
Published on: July 21, 2018
To escape or not to escape, that is the question
Ya-Cheng Liao1,2, Claudio Bussi3,4
1Department of Biochemistry & Molecular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Abstract:
Marco et al. (https://doi.org/10.1083/jcb.202507217) identify a tumor-selective endocytic route in which CD44 and EPHA2 co-traffic antisense oligonucleotides (ASOs) to nuclear-proximal, recycling-endosome-like compartments that become leaky through lipid peroxidation and show that stress granule-mediated repair of these compartments limits productive ASO escape.
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