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Updated: Aug 26, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
KDM6A suppresses proliferation and epithelial-mesenchymal transition in prostate cancer cells
Yixiu Ni1, Yijia Lin1, Wankun Wang1
1Department of Urology, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Background And Objective:
Prostate cancer is one of the most common male malignancies worldwide. KDM6A, a histone H3K27 demethylase, has been implicated in various cancers; however, its specific functions in prostate cancer remain controversial. This study aimed to investigate the regulatory role of KDM6A in castration-resistant prostate cancer (CRPC).
Methods:
We analyzed the GEO public database and conducted in vitro and in vivo experiments to examine the function of KDM6A in CRPC.
Results:
KDM6A expression was downregulated in CRPC compared with primary prostate cancer. KDM6A acted as a tumor suppressor; its depletion promoted proliferation and migration of prostate cancer cells both in vitro and in vivo. Suppression of KDM6A activated epithelial-mesenchymal transition (EMT) via HMGB2, thereby regulating the invasive behavior of prostate cancer. EMT is known to play a critical role in CRPC progression.
Conclusions:
Our findings reveal the functional role of KDM6A in CRPC and suggest its potential utility in exploring novel therapeutic strategies for CRPC.
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