Related Experiment Video
Updated: Aug 26, 2026

Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay
Published on: July 26, 2022
An uncommon side effect of statins: perioral neuropathic symptoms
1University of Florida, Gainesville, Florida, USA.
Abstract:
A male patient in his 60s, with a history of hypertension and hyperlipidaemia, presented with a sensation of dryness, itchiness, numbness and tingling around his mouth that started after taking atorvastatin, suggesting a small-fibre neuropathy related to statin use. He was prescribed statins based on increased 10-year atherosclerotic cardiovascular disease risk (9.7%) and hyperlipidaemia. This observed side effect subsided when the medication was stopped. Evaluation was conducted to rule out other underlying aetiologies of his symptoms, and it was confirmed that the statins were the cause of the symptoms when two additional repeat statin trials, with both atorvastatin and rosuvastatin, caused similar side effects that promptly resolved within a few days of stopping the medications.
Related Concept Videos
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Diabetic Neuropathy
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Peripheral Artery Disease IV: Nursing Management
Local Anesthetics: Differential Sensitivity of Nerve Fibers