Related Experiment Video
Updated: Aug 26, 2026

Biomass Conversion to Produce Hydrocarbon Liquid Fuel Via Hot-vapor Filtered Fast Pyrolysis and Catalytic Hydrotreating
Published on: December 25, 2016
Naphtha (petroleum), hydrotreated heavy: MAK Value Documentation, addendum - Translation of the German version from
1Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT) Adenauerring 20a, Building 50.41 76131 Karlsruhe Germany.
Abstract:
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and re-evaluated the data for the derivation of the occupational exposure limit value (maximum concentration at the workplace, MAK value) for naphtha (petroleum), hydrotreated heavy [64742-48-9]. Relevant studies were identified from a literature search and also unpublished study reports were used. The critical effect is preclinical neurotoxicity. The results of a 13-week study with an isoparaffinic product in rats and a behavioural toxicity study in volunteers do not contradict the previous MAK value of 50 ml/m3. The assignment to Peak Limitation Category II with an excursion factor of 2 is retained. Additionally, there are no experimental data showing that juvenile animals are more sensitive to naphtha-induced neurotoxic effects than adults. Therefore, there is no evidence that would require changing the previous categorization from Pregnancy Risk Group D to Pregnancy Risk Group B (suspected).
Related Concept Videos
Benzene to Phenol via Cumene: Hock Process
Nomenclature of Alkanes
The alkane nomenclature considers the length of the carbon chain, the number, and the location of the substituent to arrive at its systematic name. The IUPAC...
Hydrolysis of Chlorobenzene to Phenol: Dow Process
Electrophilic Aromatic Substitution: Nitration of Benzene
Electrophilic 1,2- and 1,4-Addition of HX to 1,3-Butadiene
Reduction of Benzene to Cyclohexane: Catalytic Hydrogenation

