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Updated: Aug 26, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Visible-light-promoted nickel-catalyzed cross-coupling of B-iodocarboranes with styrenes
Xueyu Wang1, Hangcheng Ni2, Zhipeng Wang3
1College of Sciences, Northeastern University Shenyang 110004 China lishimeng@neu.edu.cn.
Abstract:
A visible-light-promoted, nickel-catalyzed cross-coupling reaction of B-iodocarboranes with styrenes has been developed, enabling efficient and site-divergent alkenylation of carboranes under mild conditions. The reaction exhibits broad substrate scope, accommodating a wide range of styrene derivatives bearing various electronic and steric properties, as well as ethylene, to afford the corresponding alkenylated products in good to excellent yields. This work provides a practical and sustainable approach for carborane functionalization under ambient conditions and expands the synthetic utility of carboranyl radicals in transition metal-catalyzed Heck-type cross-coupling reactions.
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