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Updated: Aug 26, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

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Published on: November 2, 2018

Correction: Clinical and immunological characterization of NFKB1 haploinsufficiency in Japan

Kunihiko Moriya1,2, Yuji Kamiyama1,3, Ryo Ogino4

  • 1Department of Pediatrics, National Defense Medical College, Saitama, Japan.

Frontiers in Immunology
|August 25, 2026
PubMed

Keywords:
NFKB1autoimmunityautoinfammatory diseasecommon variable immunodeficiency (CVID)inborn errors of immunity (IEI)

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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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The heterodimer of NF-κB...